The reproducibility problem

Science Needs a Solution for the Temptation of Positive Results

A few years back, scientists at the biotechnology company Amgen set out to replicate 53 landmark studies that argued for new approaches to treat cancers using both existing and new molecules. They were able to replicate the findings of the original research only 11 percent of the time. Science has a reproducibility problem. And the ramifications are widespread.These 53 papers were published in high-profile journals, and the 21 that were published in the highest-impact journals were cited an average of 231 times in subsequent work. In 2011, Bayer pharmaceuticals reported similar reproduction work. ….[READ]